Pre-clinical pathology evaluation of drugs, vaccines and chemicals in toxicology studies for safety assessment

Profile

Global Pathology Support B.V. deals with preclinical safety – toxicologic pathology - for the pharmaceutical, biotechnical and chemical industry.

Services

We offer you these services applying high quality standards, in a flexible, fast and efficient way using one of the best Pathology Systems for histopathology assessment.

Toxicologic Pathologist

Dr. R.J.M.M. Thoolen was born in Breda, The Netherlands. Dr. Thoolen more than 25 years working experience as a pathologist. He worked as a principal pathologist at Solvay Pharmaceuticals.

GLOBAL PATHOLOGY SUPPORT B.V.

(GPS) is a consultancy company, founded in 2004 in the Netherlands. GPS specializes in the pre-clinical pathology evaluation of chemicals in toxicology studies for safety assessment. Our services focus on safety of products that are developed by the (bio-)pharmaceutical and chemical industry for registration of e.g. medicines, vaccines. GPS also provides services according to the Registration, Evaluation and Authorization of Chemicals (REACH) agreement for the safety evaluation of chemicals in compliance to the OECD-Guidelines.

GLP validated Digital Pathology

As part of GPS continuing commitment to enable our clients to reach their development goals, we are now excited, next to conventional histopathology using the light microscope, to also deliver innovative GLP validated Digital Pathology; Full Histopathology Evaluations and Peer Review solutions from preclinical toxicology studies on a Global scale. This option (Digital Pathology) can now also be performed from scans of histology slides from a large number of whole slide image formats (e.g. Hamamatsu, 3DHistech, Olympus, Aperio/Leica, Ventana/Roche, Philips, Zeiss scanners etc. ).

Read all the information about our new Digital Pathology services in our press release.

Vision statement
Drugs, chemicals and vaccines are safe and have no or least possible negative side effects.

Mission statement
At GPS B.V. we establish the safest dose of drugs, chemicals and vaccines by conducting toxicologic pathology research.

Member of:
NVVP - Dutch Society for Pathology
NVT – Toxicologic Society of the Netherlands
STP - Society of Toxicologic Pathology
ESTP - European Society of Toxicologic Pathology
BSTP - British Society of Toxicologic Pathology

Vision statement
Drugs, chemicals and vaccines are safe and have no or least possible negative side effects.

Mission statement
At GPS B.V. we establish the safest dose of drugs, chemicals and vaccines by conducting toxicologic pathology research.

Member of:
NVVP - Dutch Society for Pathology
NVT – Toxicologic Society of the Netherlands
STP - Society of Toxicologic Pathology
SOT - Society of Toxicology
ESTP - European Society of Toxicologic Pathology
BSTP - British Society of Toxicologic Pathology

Services

  • Histopathology assessment of toxicity and carcinogenicity studies
  • Neuropathology evaluation
  • Monitoring histology and immunohistochemistry services
  • Peer review of Pathology
  • Advisory consultant in Toxicologic Pathology
  • Gross Pathology Assessment
  • GLP validated Digital Pathology

We offer you these services applying high quality standards, in a flexible, fast and efficient way using one of the best Pathology Systems (Provantis® – Instem LSS) for histopathology assessment.

Good Laboratory Practice (GLP)

Global Pathology Support plays a key role for the delivery of sound scientific, accurate and GLP-compliant pathology data from preclinical toxicity and carcinogenicity studies. In order to do that, a GLP-compliant quality system is legally mandatory. GPS works according to Good Laboratory Practice for over 17 years now.

This guarantees our clients for over 35 countries world-wide, with GLP-compliant reports derived from GPS, that can readily be used for registration according to the respective National Authorities.

Board Certifications

News updates

Selected articles

Use of Whole Slide Images (W.S.I.’s) in Toxicologic Pathology in the Evaluation of Non-clinical GLP-Studies

Microscope? No, thanks: Use of Whole Slide Images (W.S.I.’s) in Toxicologic Pathology in the Evaluation of Non-clinical GLP-Studies

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Gastric Neuroendocrine Tumors in a 2-Year Oncogenicity Study With CD-1 Mice

Comparative immunohistochemical investigation of rat and human hepatocellular carcinomas

BrdUrd Labeling of S-Phase Cells in Testes and Small Intestine of Mice, Using Microwave Irradiation for Immunogold-Silver Staining:
An Immunocytochemical Study

Two-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure

Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa

Pre-clinical pathology evaluation of drugs, vaccines and chemicals in toxicology studies for safety assessment. Global Pathology Support B.V. deals with preclinical safety – toxicologic pathology - for the (bio-)pharmaceutical and chemical industry.

Company Info

Churchillplein 6D
2517 JW Den Haag
the Netherlands

+31 (0)70 314 24 04
+31 (0)6 461 496 05

bob.thoolen@gpstoxpath.com

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