Pre-clinical pathology evaluation of drugs, vaccines and chemicals in toxicology studies for safety assessment

Profile

Global Pathology Support B.V. deals with preclinical safety – toxicologic pathology - for the pharmaceutical, biotechnical and chemical industry.

Services

We offer you these services applying high quality standards, in a flexible, fast and efficient way using one of the best Pathology Systems for histopathology assessment.

Toxicologic Pathologist

Dr. R.J.M.M. Thoolen was born in Breda, The Netherlands. Dr. Thoolen more than 25 years working experience as a pathologist. He worked as a principal pathologist at Solvay Pharmaceuticals.

Key-role of the Toxicologic Pathologist in Safety Evaluation at Global Pathology Support

From necropsy to histopathological evaluation, interpretation and use of digital pathology

Toxicological pathology – what does it mean and what is the role of the pathologist? As regards the use of medicinal products from the pharmaceutical industry, the user's experience should be positive and the negative side effects should be kept as minimal as possible. To evaluate negative effects, toxicological studies are carried out. Studies on the toxicity of substances aim to prevent diseases by setting limiting values, below which the health risk is negligible or nil. The (toxicological) pathologist plays a crucial role in assessing the safety of vaccines, medicines and chemicals. The emphasis is on the identification of pathological changes, the evaluation and relevance of these changes, and in particular the interpretation of these data from animal experiments in the context of their application to humans (risk assessment). Catastrophes in the last century, for example after using thalidomide (teratogenic effects) and the synthetic estrogen diethylstilbestrol (DES) in utero (carcinogen) have taught us how important it is to be alert to the side effects of drugs. Contamination of food sources by pesticides and industrial waste must also be monitored. Examples of compounds that have been shown to be carcinogenic in laboratory animals (usually in relatively high doses) and that end up in low amounts in human daily food are certain pesticides (DDT and dieldrin). Also industrially contaminated substances need thorough preclinical safety evaluations (e.g., Polychlorinated Biphenyls, Per- and Polyfluoroalkyl substances (PFAS). Moreover, the fact that more and more drugs are withdrawn from circulation after launch also highlights the importance of safety evaluation, in which the Toxicological Pathologist plays a crucial role.

At Global Pathology Support B.V. we provide preclinical pathology support in a GLP-compliant manner (Good Laboratory Practice) for the histopathological assessment of toxicology studies which plays a major role in the safety evaluation of compounds tested. We also use “Whole Slide Images“(W.S.I.’s) in the evaluation of non-clinical GLP-studies by the Board Certified Toxicologic Pathologist.

Whole slide images (W.S.I.’s) have become an essential modern tool for toxicologic pathology in the evaluation of non-clinical GLP-studies. The use of W.S.I.’s in toxicologic pathology has revolutionized the way pathological data is collected, analyzed, and communicated. The additional option for evaluating scans of slides (W.S.I.’s) by the Toxicologic Pathologist is more efficient and has other benefits. 

GLOBAL PATHOLOGY SUPPORT B.V.

(GPS) is a consultancy company, founded in 2004 in the Netherlands. GPS specializes in the pre-clinical pathology evaluation of chemicals in toxicology studies for safety assessment. Our services focus on safety of products that are developed by the (bio-)pharmaceutical and chemical industry for registration of e.g. medicines, vaccines. GPS also provides services according to the Registration, Evaluation and Authorization of Chemicals (REACH) agreement for the safety evaluation of chemicals in compliance to the OECD-Guidelines.

As part of GPS continuing commitment to enable our clients to reach their development goals, we are now excited, next to conventional histopathology using the light microscope, to also deliver innovative GLP validated Digital Pathology; Full Histopathology Evaluations and Peer Review solutions from preclinical toxicology studies on a Global scale. This option (Digital Pathology) can now also be performed from scans of histology slides from a large number of whole slide image formats (e.g. Hamamatsu, 3DHistech, Olympus, Aperio/Leica, Ventana/Roche, Philips, Zeiss scanners etc).

Read all the information about our new Digital Pathology services in our press release.

Vision statement
Drugs, chemicals and vaccines are safe and have no or least possible negative side effects.

Mission statement
At GPS B.V. we establish the safest dose of drugs, chemicals and vaccines by conducting toxicologic pathology research.

Member of:
NVVP - Dutch Society for Pathology
NVT – Toxicologic Society of the Netherlands
STP - Society of Toxicologic Pathology
ESTP - European Society of Toxicologic Pathology
BSTP - British Society of Toxicologic Pathology

Vision statement
Drugs, chemicals and vaccines are safe and have no or least possible negative side effects.

Mission statement
At GPS B.V. we establish the safest dose of drugs, chemicals and vaccines by conducting toxicologic pathology research.

Member of:
NVVP - Dutch Society for Pathology
NVT – Toxicologic Society of the Netherlands
STP - Society of Toxicologic Pathology
SOT - Society of Toxicology
ESTP - European Society of Toxicologic Pathology
BSTP - British Society of Toxicologic Pathology

Services

  • Histopathology assessment of toxicity and carcinogenicity studies
  • Neuropathology evaluation
  • Monitoring histology and immunohistochemistry services
  • Peer review of Pathology
  • Advisory consultant in Toxicologic Pathology
  • Gross Pathology Assessment
  • GLP validated Digital Pathology

We offer you these services applying high quality standards, in a flexible, fast and efficient way using one of the best Pathology Systems (Provantis® – Instem LSS) for histopathology assessment.

Good Laboratory Practice (GLP)

Global Pathology Support plays a key role for the delivery of sound scientific, accurate and GLP-compliant pathology data from preclinical toxicity and carcinogenicity studies. In order to do that, a GLP-compliant quality system is legally mandatory. GPS works according to Good Laboratory Practice for over 17 years now.

This guarantees our clients for over 35 countries world-wide, with GLP-compliant reports derived from GPS, that can readily be used for registration according to the respective National Authorities.

Board Certifications

News updates

Selected articles

WSI evaluation

Use of Whole Slide Images (W.S.I.’s) in Toxicologic Pathology in the Evaluation of Non-clinical GLP-Studies

Microscope? No, thanks: Use of Whole Slide Images (W.S.I.’s) in Toxicologic Pathology in the Evaluation of Non-clinical GLP-Studies

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Gastric Neuroendocrine Tumors in a 2-Year Oncogenicity Study With CD-1 Mice

Comparative immunohistochemical investigation of rat and human hepatocellular carcinomas

BrdUrd Labeling of S-Phase Cells in Testes and Small Intestine of Mice, Using Microwave Irradiation for Immunogold-Silver Staining:
An Immunocytochemical Study

Two-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure

Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa

We have worked for:
Pre-clinical pathology evaluation of drugs, vaccines and chemicals in toxicology studies for safety assessment. Global Pathology Support B.V. deals with preclinical safety – toxicologic pathology - for the (bio-)pharmaceutical and chemical industry.

Company Info

Churchillplein 6D
2517 JW Den Haag
the Netherlands

+31 (0)70 314 24 04
+31 (0)6 461 496 05

bob.thoolen@gpstoxpath.com

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