Publications

Dr Robertus J.M.M. Thoolen, PhD, CRP/TP
Board Certified Toxicologic Pathologist

PUBLICATIONS

Major contributions to approved internal reports; FDA submissions, IDB, NDAs, Expert reports and Appraisals of Solvay Pharmaceuticals B.V. – Titles not presented.

Bob Thoolen. The mouse renal system – A summary of histopathological findings. Dept. Veterinary Pathology, Div. Pathology of Laboratory and special animal diseases, November 1988; 16 pp.

Bob Thoolen. Rat – Histopathology of the renal system – A summary of histopathological findings. Dept. Veterinary Pathology, Div. Pathology of Laboratory and special animal diseases, November 1988; 18 pp.

BrdUrd labeling of S-Phase Cells in Testes and Small Intestine of Mice, Using Microwave Irradiation for Immunogold-Silver Staining: An Immunocytochemical Study. The J. Histochem. & Cytochem. 1990; 38(2):267-273.

Bob Thoolen. Malignant Fibrous Histiocytoma – a histogenetic study – The J. Comp. Pathol. 1990 (Submitted).

R.J.M.M. Thoolen, J.H. Vos, J.S. van der Linde-Sipman, R.A. de Weger, J.A.M. van Unnik, W. Misdorp and J.E. van Dijk. Malignant Fibrous Histiocytomas in Dogs and Cats – An Immunohistochemical Study – Res. Vet Sci. 1992; 53:198-204.

Bob Thoolen, Henk Koster, Anton van Kolfschoten & Martin de Haan. Gastric neuroendocrine tumours in a two-year oncogenicity study with CD-1 mice. Toxicol Pathol 2002; 30 (3):322-327.

Ben A.R. Lina, Ruud A. Woutersen, Joost A. Bruijntjes, Jan van Benthem, Jolanda A.H. van den Berg, Johan Monbaliu, Bob J.M.M. Thoolen, Rudolf B. Beems and Coen F. van Kreijl. Evaluation of the Xpa-Deficient Transgenic Mouse Model for Short-Term Carcinogenicity Testing: 9-Month Studies with Haloperidol, Reserpine, Phenacetin, and D-Mannitol. Toxicol Pathol 2004; 32 (2):192-201.

Baras B, Stittelaar KJ, Simon JH, Thoolen RJMM, Mossman SP, et al. (2008) Cross-Protection against Lethal H5N1 Challenge in Ferrets with an Adjuvanted Pandemic Influenza Vaccine. PLoS ONE 3(1): e1401. doi:10.1371/journal.pone.0001401.

Bob Thoolen, Robert R. Maronpot, Takanori Harada, Abraham Nyska, Colin Rousseaux, Thomas Nolte, David E. Malarkey, Wolfgang Kaufmann, Karin Küttler, Ulrich Deschl, Dai Nakae, Richard Gregson, Michael P. Vinlove, Amy E. Brix, Bhanu Singh, Fiorella Belpoggi1, Jerrold M. Ward.Nomenclature and Diagnostic Criteria for Hepatobiliary Lesions in Rats and Mice (INHAND) Toxicol Pathol 2010; 38:5S-81S.

Jerald M. Ward and Bob Thoolen. Grading of Lesions. Toxicol Pathol 2011; 39:745-746.

Bob Thoolen, Fiebo J.W. ten Kate, Paul J. van Diest, David E. Malarkey, Susan A. Elmore and Robert R. Maronpot. Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions. J Toxicol Pathol 2012;23:23-36.

Bob Thoolen, Fiebo J.W. ten Kate, Domenico Castigliego, Paul J. van Diest, David E. Malarkey, Susan A. Elmore and Robert R. Maronpot. Comparative Immunohistochemical Investigation of Rat and Human Hepatocellular Carcinomas. J Toxicol Pathol 2012 (Accepted).

Bob Thoolen, Fiebo J.W. ten Kate, Domenico Castigliego, Paul J. van Diest, David E. Malarkey, Susan A. Elmore and Robert R. Maronpot. Immunohistochemical Research on Human and Rat Hepatocellular Proliferative Lesions. J Histochem & Cytochem (Manuscript in preparation).

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