通过毒理学研究对药物、疫苗和化学品进行临床前病理评估,进而对产品的安全性做出评价。

公司简介

Global Pathology Support B.V.致力于为生物制药和化工产品处理基于毒理病理学研究基础上的临床前安全性问题。

公司服务

高质量、高标准的服务是我们的宗旨。我们使用最好的病理系统之一(Provantis® - Instem LSS)进行组织病理学评估。灵活、快速、高效是我们一贯的服务理念。

毒理学病理学家

Dr. R.J.M.M. Thoolen was born in Breda, The Netherlands. Dr. Thoolen more than 25 years working experience as a pathologist. He worked as a principal pathologist at Solvay Pharmaceuticals.

Key-role of the Toxicologic Pathologist in Safety Evaluation at Global Pathology Support

From necropsy to histopathological evaluation, interpretation and use of digital pathology

Toxicological pathology – what does it mean and what is the role of the pathologist? As regards the use of medicinal products from the pharmaceutical industry, the user's experience should be positive and the negative side effects should be kept as minimal as possible. To evaluate negative effects, toxicological studies are carried out. Studies on the toxicity of substances aim to prevent diseases by setting limiting values, below which the health risk is negligible or nil. The (toxicological) pathologist plays a crucial role in assessing the safety of vaccines, medicines and chemicals. The emphasis is on the identification of pathological changes, the evaluation and relevance of these changes, and in particular the interpretation of these data from animal experiments in the context of their application to humans (risk assessment). Catastrophes in the last century, for example after using thalidomide (teratogenic effects) and the synthetic estrogen diethylstilbestrol (DES) in utero (carcinogen) have taught us how important it is to be alert to the side effects of drugs. Contamination of food sources by pesticides and industrial waste must also be monitored. Examples of compounds that have been shown to be carcinogenic in laboratory animals (usually in relatively high doses) and that end up in low amounts in human daily food are certain pesticides (DDT and dieldrin). Also industrially contaminated substances need thorough preclinical safety evaluations (e.g., Polychlorinated Biphenyls, Per- and Polyfluoroalkyl substances (PFAS). Moreover, the fact that more and more drugs are withdrawn from circulation after launch also highlights the importance of safety evaluation, in which the Toxicological Pathologist plays a crucial role.

At Global Pathology Support B.V. we provide preclinical pathology support in a GLP-compliant manner (Good Laboratory Practice) for the histopathological assessment of toxicology studies which plays a major role in the safety evaluation of compounds tested. We also use “Whole Slide Images“(W.S.I.’s) in the evaluation of non-clinical GLP-studies by the Board Certified Toxicologic Pathologist.

Whole slide images (W.S.I.’s) have become an essential modern tool for toxicologic pathology in the evaluation of non-clinical GLP-studies. The use of W.S.I.’s in toxicologic pathology has revolutionized the way pathological data is collected, analyzed, and communicated. The additional option for evaluating scans of slides (W.S.I.’s) by the Toxicologic Pathologist is more efficient and has other benefits. 

全球病理学支持中心

全球病理学支持中心,简称 (GPS) 于2004年在荷兰成立。专注于毒理学研究中化学品的临床前病理学评估,进而对产品的安全性做出评价。我们专注于评估生物制药和化工行业开发的产品的安全性,如药品、疫苗的注册等。我们的服务是完全符合欧洲化学品管理局的注册、评估、许可和限制法案的(REACH)。并且我们所有的化学品安全评估都合乎经合组织(OECD)准则。

As part of GPS continuing commitment to enable our clients to reach their development goals, we are now excited, next to conventional histopathology using the light microscope, to also deliver innovative GLP validated Digital Pathology; Full Histopathology Evaluations and Peer Review solutions from preclinical toxicology studies on a Global scale. This option (Digital Pathology) can now also be performed from scans of histology slides from a large number of whole slide image formats (e.g. Hamamatsu, 3DHistech, Olympus, Aperio/Leica, Ventana/Roche, Philips, Zeiss scanners etc).

在网站新闻稿中阅读更多关于数字病理学服务的信息

企业愿景
确保药品、化学品和疫苗的安全性。消除其副作用,以及将产生副作用的可能性降到最低。

企业宗旨
我们致力于通过科学的毒理学病理学研究,确定药物、化学品和疫苗的最安全剂量。

组织成员
NVVP - 荷兰病理学会
NVT - 荷兰毒理学会
STP - 毒物学病理学会
ESTP - 欧洲毒物学病理学会
BSTP - 英国毒物学病理学会

企业愿景
确保药品、化学品和疫苗的安全性。消除其副作用,以及将产生副作用的可能性降到最低。

企业宗旨
我们致力于通过科学的毒理学病理学研究,确定药物、化学品和疫苗的最安全剂量。

组织成员
NVVP - 荷兰病理学会
NVT - 荷兰毒理学会
STP - 毒物学病理学会
SOT - 毒理学会
ESTP - 欧洲毒物学病理学会
BSTP - 英国毒物学病理学会

公司服务

  • 毒性和致癌性研究的组织病理学评估
  • 神经病理学评估
  • 监测组织学和免疫组织化学服务
  • 病理学同行评议
  • 毒理学病理学咨询顾问
  • 大体病理学评估
  • 优良实验室规范(GLP)认证的数字病理学

高质量、高标准的服务是我们的宗旨。我们使用最好的病理系统之一(Provantis® - Instem LSS)进行组织病理学评估。灵活、快速、高效是我们一以贯之的服务理念。

优良实验室规范(GLP)

企业符合优良实验室规范(GLP)的质量体系是具有法律强制效应的。而我们在提供科学合理、准确和符合优良实验室规范(GLP)要求的临床前毒性和致癌性研究的病理学数据方面发挥着不可替代的作用。让我们引以为傲的是全球病理学支持中心已经合乎规范的走过了17年了。

标准化的评估和测试确保我们在全球超过35个国家的客户可以获得我公司符合良好实验室(GLP)要求的合规报告。而且这些报告可以随时用于按照各个国家当局的要求进行注册。

Board Certifications

News updates

Selected articles

WSI evaluation

Use of Whole Slide Images (W.S.I.’s) in Toxicologic Pathology in the Evaluation of Non-clinical GLP-Studies

Microscope? No, thanks: Use of Whole Slide Images (W.S.I.’s) in Toxicologic Pathology in the Evaluation of Non-clinical GLP-Studies

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Gastric Neuroendocrine Tumors in a 2-Year Oncogenicity Study With CD-1 Mice

Comparative immunohistochemical investigation of rat and human hepatocellular carcinomas

BrdUrd Labeling of S-Phase Cells in Testes and Small Intestine of Mice, Using Microwave Irradiation for Immunogold-Silver Staining:
An Immunocytochemical Study

Two-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure

Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa

We have worked for:
通过毒理学研究对药物、疫苗和化学品进行临床前病理评估,从而对产品的安全性做出评价。全球病理学支持中心为生物制药和化学工业处理基于毒理病理学研究基础上的临床前安全性问题。

公司信息

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